However, at near lethal doses in rats, increases in serum aspartate aminotransaminase (SGOT), alanine aminotransaminase (GTP), and lactic dehydrogenase. Biochemical and histological alterations induced by the smoke of allethrin based SGOT – Glutamate oxaloacetate transaminase ยท Lung Diseases, Obstructive. Most type I pyrethroids (eg, permethrin, allethrin, biuallethine, cismethrin, .. liver dysfunction (an increase in serum-alkaline phosphatase (SAP), SGOT, and.

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Skip to search form Skip to main content. Although the eventual responsive treatment supported by the microscopy findings strongly suggest a case of scabies, the preliminary diagnosis of dermatosis due to peptic ulcer disease was equally supported by allethriin positive ELISA as well as a sustained elevation of serum CRP and marked eosinophilia.

Ready to take your reading offline? Death in animals occurs within 3 days stot exposure to permethrin. Written informed consent was obtained from the patient for publication of this case study and any accompanying images. The results of hematology, clinical chemistry, urinalysis, and ophthalmological examinations were also normal.

Microscopically, hepatocellular swelling occurred, which has been attributed to increased microsomal activity resulting in a proliferation of endoplasmic reticulum. Mortality, growth, and food consumption were normal in all dose groups. No clinical signs of. Close skin contacts such as family members and sexual partners are the commonly mentioned modes of transmission.

This case proved particularly challenging and confirmatory diagnosis was only achieved towards convalescence. Page 49 Share Cite. Looking for other ways to read this? None died, and all animals exhibited normal growth and normal food and water consumption.


Page 47 Share Cite. The non-classic presentation of scabies presents a challenging case to the clinician. Page 48 Share Cite. None died, and growth and food consumption of allehhrin animals were normal.

Although the data on dermal toxicity from subacute exposures are scanty, the available information shows that alletyrin exposure to permethrin is unlikely to cause dermal effects.

Although nosocomial scabies is perceived to be of rare occurrence, a high-risk index and history of exposure are leading indicators of suspicion, while the typical dermatological pattern with a persistent nocturnal itch justify a confirmatory examination [ 1417 ]. Abdulla Al-Mamun and M. Food consumption and growth as well as clinical chemistry, hematological, and urinalysis values were normal. No mortality was seen.

Do you enjoy reading reports from the Academies online for free? All rats surviving to term were killed, and various tissues and organs from each animal were examined histopathologically.

However, the animals gained weight rapidly after the dosing period, and no differences in body weight between control and permethrin-treated animals were observed at the end of the study period.

Urinalysis and hematological and clinical biochemistry values were allethrih normal limits. Significant increases in absolute and relative liver weights were observed at the two highest doses. Histopathological examination of tissues and organs of the animals receiving.

A complicated case of scabies in a health care provider

By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy PolicyTerms of Serviceand Dataset License. A 34 year old, male healthcare alletrin presented at the referral dermatology clinic of Kilimanjaro Christian Medical Centre with persistent rash on his lower legs that was itchy especially at night Figure 1. Most of the studies of synthetic pyrethroids involved workers applying the chemicals for fly control Prinsen and van Alletbrin, A moderate primary irritation of the skin was produced by permethrin.


Showing of 42 references. Page 53 Share Cite.

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At the end of the feeding regimen, rats were either killed or maintained on control diets and sacrificed 1, 4, or 8 weeks after termination of dosing. No significant toxic effects were seen in rabbits or cows administered permethrin for 10 or 28 days, respectively. However, at near lethal doses in rats, increases in alltehrin aspartate aminotransaminase SGOTalanine aminotransaminase GTPand lactic alllethrin LDH enzymes were reported, which suggest some liver toxicity.

Effect of continuous inhalation of allethrin-based mosquito coil smoke in the male reproductive tract of rats. There were no significant hematological or clinical chemistry findings.

At early presentation a full heamogram and serology tests for liver and renal function were done after a cursory physical examination. Page 56 Share Cite. Allthrin images of adult mites in skin scrapings 10 weeks mounted in KOH: